Megaprosthesis

What is a megaprosthesis?

A megaprosthesis (also known as a massive endoprosthesis or tumour prosthesis) is a specialised implant used to replace a joint and a large segment of bone. It is typically used following tumour resection or where trauma or infection have resulted in significant bone loss.

Indications and contraindications for megaprostheses.

Megaprostheses are typically utilised for the treatment of conditions which have resulted in large bone defects. These include:

Bone tumour resection: where excision has included a substantial margin of health bone and tissue.

Massive traumatic bone loss: substantial loss resulting from high-energy trauma.

Chronic infection (osteomyelitis): where treatment neccesitates the removal of dead and infected bone.

Failed reconstruction: where previous surgery has proved unsuccessful. 

 

Contraindications for megaprosthesis include:

Poor general health, including uncontrolled diabetes, immune compromise and severe cardiovascular disease.

Active infection (local or general).

Vascular insufficiency, including avascular necrosis.

Insufficient soft tissue coverage.

Benefits and complications of megaprostheses

Benefits

  • Restoration of function and stability.
  • Improvements in quality of life.
  • Reduced pain.
  • Durability of modern implants delivers long-term benefits.

Known complications

  • Permanent nerve damage resulting in sensory or motor deficits.
  • Superficial or deep infection
  • Vascular injury and bleeding.
  • Pain.
  • Implant loosening or failure.
  • Bone resorption, compromising implant stability. 
  • Deep Vein Thrombosis (DVT)

The surgery

Megaprostheses may take one of several forms. These include segmental megaprosthesis, which may be used to replace large sections of long bone and often includes an adjacent joint replacement; modular megaprosthesis which allow customisation of available components and custom-made megaprosthesis, where neither segmental or modular options are appropriate. Megaprosthesis implant may also be combined with graft or transfer procedures to improve outcomes.

Preparation prior to surgery

  • You will receive a thorough health assessment: including medical history. You may be advised to modify certain lifestyle factors and you may be referred to another specialist. You may be asked to stop taking certain medications as your surgery date approaches. X-rays, CT scans, and MRIs will be used to evaluate your condition and plan your surgery.  
  • Skin and bowel preparation: On the evening before your surgery, you will be asked to wash your leg using the sponge provided at your pre-admission clinic. A skin test may be administered if an iodine allergy is suspected. You will also be provided medicine to help you evacuate your bowels prior to surgery.
  • Patient education: if neccessary, you may speak with a physiotherapist who can advise you on post-operative mobility. 

 

On the day of the surgery

  • You will be asked to complete your surgical paperwork and will meet with the anaesthetist.
  • The surgical site will be prepared.
  • You will be administered general or spinal anaesthesia.
  • An incision will be made over the target area.
  • Dead and damaged bone and soft tissue will be removed.
  • An appropriate implant will be fitted and adjunct steps taken to stablise the bone around the implant, as required. Alignment and stability will be confirmed by x-ray.
  • Soft tissue will be managed, sometimes with the support of a plastic surgeon.
  • Closure: The incision is closed using sutures. A dressing will be applied and vacum assisted wound closure may be used, if appropriate. Your limb may be immobilised. 

 

After your surgery

  • In-patient care: you will remain in hospital for several days for monitoring and early-stage rehabilition. 
  • Pain and swelling: You may experience mild to moderate pain. You will be prescribed painkillers to manage these symptoms. Inflammation can be controlled by icing (15 minutes per hour maximum) and elevation.
  • Mobilising: you may be fitted with a cast or splint after your surgery. How long it remains in place will be determined by the nature of your procedure and your recovery. You will be unable to weightbear during this period. Once weightbearing is indicated, you can begin gradually, using crutches, boots or brace protection, under clinical supervision. 
  • Aftercare: at one week post-surgery, you will be required to attend a wound check and at two weeks your sutures will be removed and further x-rays may be taken. At 6 weeks, you will undergo further X-rays to assess healing, and at three months after your surgery for the same reason. You may be prescribed blood thinners to reduce the risk of a clot developing. 
  • Physiotherapy: you recovery will be supported by a tailored physiotherapy protocol. 

Concerns

If you are concerned about your pain level, or develop significant bleeding, fever or redness around the surgical site, please contact us immediately. For after-hours support, contact the hospital at which your surgery was completed. They will contact Prof. Al Muderis on your behalf.

Norwest Private Hospital(02) 8882 8882

Macquarie University Hospital: (02) 9812 3000